Biologically Active Heteroglycoclusters Constructed on a Pillar[5]arene‐Containing [2]Rotaxane Scaffold

نویسندگان

  • Stéphane P. Vincent
  • Kevin Buffet
  • Iwona Nierengarten
  • Anne Imberty
  • Jean‐François Nierengarten
چکیده

A synthetic approach combining recent concepts for the preparation of multifunctional nanomolecules (click chemistry on multifunctional scaffolds) with supramolecular chemistry (self-assembly to prepare rotaxanes) gave easy access to a large variety of sophisticated [2]rotaxane heteroglycoclusters. Specifically, compounds combining galactose and fucose have been prepared to target the two bacterial lectins (LecA and LecB) from the opportunistic pathogen Pseudomonas aeruginosa.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Thermally responsive shuttling behavior of a pillar[6]arene-based [2]rotaxane.

A [2]rotaxane constructed from a per-ethylated pillar[6]arene as a wheel and a pyridinium derivative as an axle was prepared. The wheel segment of the per-ethylated pillar[6]arene moved from one station to another along the axle as a result of thermal stimuli.

متن کامل

A [2]rota[2]catenane, constructed from a pillar[5]arene-crown ether fused double-cavity macrocycle: synthesis and structural characterization.

A topologically novel [2]rota[2]catenane containing both a pillar[5]arene-imidazolium based [2]rotaxane subunit and a crown ether-tetracationic cyclophane based [2]catenane one was designed and constructed. The structure of the [2]rota[2]catenane was thoroughly characterized by NMR spectra, MS spectrometry and single crystal X-ray diffraction analysis.

متن کامل

Förster resonance energy transfer by formation of a mechanically interlocked [2]rotaxane.

A [2]rotaxane has been constructed from a di-pyrene appended pillar[5]arene wheel, a pyridinium axle, and a perylene stopper. It shows efficient Förster resonance energy transfer from pyrene to perylene by formation of a mechanically interlocked [2]rotaxane.

متن کامل

Design and efficient synthesis of a pillar[5]arene-based [1]rotaxane.

A pillar[5]arene-based [1]rotaxane was simply prepared in a high yield of 73%. Its stucture was confirmed by (1)H NMR, 2D NMR spectra, mass spectra and theoretical calculation.

متن کامل

Multistimuli Sensitive Behavior of Novel Bodipy‐Involved Pillar[5]arene‐Based Fluorescent [2]Rotaxane and Its Supramolecular Gel

Fluorescent [2]rotaxane BC12P5 is successfully constructed with 1,4-diethoxypillar[5]arene as wheel over a long alkyl axle with Bodipy chromophore as one stopper for the first time. NMR spectra clearly reveal its molecular shuttle nature triggered by multiple external stimuli including solvent polarity and temperature. In particular, the fluorescence nature introduced into [2]rotaxane BC12P5 re...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 22  شماره 

صفحات  -

تاریخ انتشار 2016